Brabec de Mori (2011, p. 24, 42), in his densely argued text, reports a scholarly consensus that the original homeland of the Ayahuasca vine and its related shamanic practice was precisely north of the Amazon in the valley of the Napo river where its made the preparation of Ayahuasca tea and the practice of spirituals cerimonies to heal the heart and the spirit has spread over the course of several centuries, southward along the great river valleys, and eastward into Madre de Díos and beyond. The Napo river basin, lying north of Iquitos, connects to the Andean highlands through the accessible Papallacta pass—presumably an ancient trade route, the name papallacta meaning “potato town.” The Napo river in turn connects to the immense thoroughfare of the Amazon river, where it grows the greatest quantitate of Ayahuasca´s vine and the Chacruna´s leaf.
Zuluaga (2004, p. 132), an expert on traditional Colombian medicine, claims that it is precisely in the western Amazonian lowlands around the Napo river where the Ayahuasca vine can still be found in its wild form; elsewhere, he says, the vine is found only in cultivated form, grown from seeds carried by indigenous people and exchanged in trade.
Ayahuasca began its great exodus inadvertently by the Spanish conquerors. During the Spanish conquest, when indigenous people were forced to live together for protection it brought together Shaman from different tribes to share their practices and discoveries, accelerating a cultural and medicinal exchange (Beyer, 2010, p. 282).